The World's Purest CBD

We have embarked on new frontiers in pharmaceutical therapeutics, nutritional significance and the dietary algorithms for understanding disease causation and the corrective nutritional dietary programs for disease prevention. The conceptual validation, using scientific research and confirmation that nutrients are the key to genetic (genomic) signaling is now a foundational reality. Dietary intake is responsible for not only supplying the body’s cellular machinery with a fuel substrate but with the correct signaling information machinery to its own genomic core; to allow the variable genetic coding the ability to respond through transcription with up-regulation, down-regulation, inhibition and/or stimulation, establishing end-organ responses. One may draw and analogy with the amazing multi-signaling component of CBD Maximum wherein the natural growth factors are believed to manifest new and exciting signaling capacities. One may make an analogy wherein the ingredients in CBD Maximum are thought to act as “ligands” to receptors or intra-cellular and intra-nuclear sensors. As a result of these actions we can reasonably propose that a complex cascade of reactions occurs creating healthy aging, genetic balance and disease prevention in the organism.

CBD Maximum formula contains oligopeptides patented extract derived from laboratory-grade chicken (Gallus Gallus) fertilized and partially incubated hen eggs reach in natural Growth Factors, 100 % pure CBD crystallized powder, Fulvic Humic acid and BCCA. Growth Factors are thought to act as “ligands” to receptors or intra-cellular and intra-nuclear sensors.

A ligand that can bind to a receptor, alter the function of the receptor, and trigger a physiological response is called an agonist for that receptor.

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

CBD Maximum contains all the natural catalog stem cell biosimilar microRNAs, endogenous pep-tides, growth factors and pluripotent Yamanaka factors. This catalog includes; Activin ,IGF-1, IGF-2, FGF (fibroblast growth factors), NGF (nerve growth factors), EGF (epidermal growth factors), CTGF (connective tissue growth factors), Immunoglobulins, Immune-Regulating Anti-Inflammatory Cytokines, and TGF (Transforming Growth Factor Beta) Follistatin, Thymosin B4.

These growth factors act as bio-signaling molecules (Radecki, et al, 1997; Martinez-Maqueda, et al, 2012; Kousaku, 2011). Recent studies on the role of miRNAs in reprogramming and therapeutic strategies may explain the benefits derived from chicken egg extract.

Reprogramming cells has been the subject of many scientific studies since the early 1900s. In 1962, John B. Gurdon’s research proved that cellular differentiation is achieved through transplantation. Dr. Shinya Yamanaka (2012) also proved that the introduction of transcription factors into a differentiated cell can indeed convert the cell into a pluripotent state. Yamanaka’s research concluded that matured cells can be reprogrammed to replicate. In 2012, Dr. Yamanaka and Dr. Gurdon both received a Nobel Prize in Physiology for their discovery of mature cells being able to be reprogrammed to a pluripotent state (Yamanaka, 2006).

Researchers Onder and Daley (2011) declared that miRNAs are macro players in somatic cell reprogramming and that miRNA-based reprograms “faster than the standard four-factor reprogramming” method such as the Yamanaka factors. In addition, the authors suggest that miRNA-based reprogramming is more significant and practical way to generate pluripotent stem cell induction (Onder & Daley, 2011).

CBD Maximum formula contains Fulvic and Humic Acid

Fulvic and Humic acid plays an integral role in your body's ability to properly absorb nutrients at the cellular level. It works by entering into your cells and serving as a discriminate toward minerals, helping choose what minerals to keep out of the cell and what minerals to bring in through the membrane--and at what quantities--in order for the cell to function properly with well-balanced nutrients. This improves the overall health of the cell and the functioning of the cell, since it has greater access to the organic materials needed to perform its necessary functions.

Because Fulvic and Humic acid provides electrolytes that enhance the electric potential of cells, this can also benefit mineral deficiencies that may be rooted at the cellular level. For example, deficiencies of iron, calcium and magnesium can be more difficult for your cells to absorb without adequate levels of fulvic acid present in the body. An individual's overall electric potential can be negatively impacted by the loss of fluids, emotional stress, sleep deprivation or poor diet. Improving the electric balance in your cells can help defend your body against sickness, weakness and other problems associated with low energy levels.

Fulvic and Humic are also known for their abilities to support the body in detoxification, removal of heavy metals, and reducing harmful side-effects of radiation treatment. If you are on chemotherapy or receiving radiation treatments remember to consult with your doctor before taking Fulvic & Humic acid.

With all of these benefits, Fulvic Acid is an effective treatment for a wide range of conditions. The compound can be used to treat neural pain, diminished brain function, degenerative diseases and a variety of others.

BCAA. Results of a 1999 study suggest that BCAA’s might improve the symptoms of tardive dyskinesia, a movement disorder caused by long-term use of antipsychotic drugs

CBD Maximum has a variety of potential health benefits, including strength, stamina, focus, improved sleep, boost the immune system, increased libido, alleviate gout symptoms, support bone density, supports probiotics, sense of wellbeing, and is one of the most powerful free radical scavenger.

CBD Maximum not only provides a mechanism for rapid transport of very critical nutrients to the body, but also contains many growth factors, one of them is Fibroblast Growth Factor, (see below) which is responsible for the amino acids and peptides to be utilized in the right manner, by directing their correct use by the body. The growth factor is also responsible for nurturing the body’s own stem cells both differentiated, and undifferentiated. Having a perfectly balanced, natural, transport mechanism, with a strong “director” such as CBD Maximum you will be assured that the added CBD would not only find their way to the right areas of the body, but verifiably, are guided properly to perform their function efficiently.

Fibroblast Growth Factor (FGF.) essential in supporting embryonic development. While FGF is readily available in the human placenta, its availability diminishes over time, and essentially vanishes as we age. Our body by itself is incapable of producing its own FGF, which it must derive from the food supply.

Research and clinical trials credits FGF with improving neuron functions in your brain, increasing amino acids and peptides in your cells and assigning the proper stem cells to restore your body’s organs back to their original state.

FGF reprograms adult stem cells and amino acids in your body, which make up your natural repair tools, to travel to the areas of your body that need it most. Once there, these repair tools have the ability to integrate themselves with that particular body part. Their mission then becomes to repair and regenerate the cells and tissue in that location, wherever it is in the body.

1. Our stem cells gather around trauma sites (old and new) waiting for repair instructions from the signal molecules. However, many of the signal molecules have become dormant during the aging process.

2. CBD Maximum supports to reactivate the body’s signal molecule communication with the stem cells. When the communication circuits ‘wake up’ from dormancy, the stem cell instructions initiate the repair process where needed.

3. Another major benefit: The Nervous System requires highly balanced levels of serotonin & neurotransmitters, CBD Maximum balances serotonin and neurotransmitter levels in the body

…hence repair to the central nervous system communication occurs, enabling it to send messages to areas of the body that are awaiting repair.

FGF is responsible for building the linings in the blood vessels, creating the infrastructure for the nutrients to flow to critical areas of the brain and organs. Research credits FGF with the potential to directly affect many neuro disorders because of clear results of the ability of FGF to affect the growth of neurites. Neurites are signal senders (Axons) and signal receivers (dendrites) attached to the brain neurons. FGF growth factors are messengers that mediate intercellular communication and adult stem cell differentiation.

Research has also shown clearly that new cell cultures show a dramatic increase in peptide and amino acid uptake in the presence of FGF. This result gives credence to the hypothesis that embryonic growth is influenced by a very precise mechanism, which combines unique combinations of amino acids, peptides and FGF

Fundamental to the research is the fact discovered by Altman, J. in 1962 that neural STEM cells are formed by the body in response to abnormalities, and are resident in certain zones of the brain. The brain is therefore ready to repair the damage, and these cells have shown to differentiate into a wide range of neurons. Neurons derived from such neural stem cells are capable of migrating to various regions of the Central Nervous System.

By incorporating Growth Factors, Fulvic Acid and BCCA to CBD it will add additional benefits and increase the effectiveness of the product.

oligopeptides adds a synergistically potent composition to CBD and helps to activate the CBD receptors via ligand. Another important benefit to Growth Factors is the ability to activate satellite cells which play an important roll in normal skeletal muscle growth (increase in muscle mass) and repair. Ref. International Journal of Stem Cell Vol.3,No.1, 2010

         CBD Maximm Mechanism of Action

These peptides have a demonstrated adaptogenic effect and act at TWO levels:

1) Normalize the adrenal cortex activity (androgens, gluco-corticoids, and mineral-corticoids); and

2) At the cellular/tissue level, exert cyto-stimulating, cyto-protective and anti-oxidative properties).

Some of the natural growth factors and peptides it contains are;

•Activin enhances FSH biosynthesisand secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis,^[3] metabolism, homeostasis, immune response, wound repair,^[4] and endocrine function

• IGF-1, IGF-2 (insulin-like growth factor-1,2)- which play important roles in growth and development. IGF-1 mediates many of the growth-promoting effects of growth hormone, while IGF-2 is essential to liver, kidney, and brain function.

• FGF fibroblast growth factors are multifunctional proteins with a wide variety of effects; they are most commonly mitogens but also have regulatory, morphological, and endocrine effects. They have been alternately referred to as "pluripotent" growth factors and as "promiscuous" growth factors due to their multiple actions on multiple cell types. Promiscuous refers to the biochemistry and pharmacology concept of how a variety of molecules can bind to and elicit a response from single receptor. In the case of FGF, four receptor subtypes can be activated by more than twenty different FGF ligands..

• NGF (nerve growth factors)- peptides that promote neural cell regeneration.

• EGF (epidermal growth factors)- peptides that promote tissue growth and development as well as helping with wound healing.

• CTGF (connective tissue growth factors)- peptides that promote collagen production in the body and help with cartilage regeneration.

• TGF-β (transforming growth factors)- peptides that important in regulation of the immune system and plays a crucial role in the regulation of the cell cycle.

• FOLLISTATIN (also known as activin-binding protein), is involved in the development of the embryo and is part of the inhibin-activin-follistatin axis. Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee & McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass.^[3][4] In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength. This research paves the way for human clinical trials, which are hoped to begin in the summer of 2010 on Inclusion body myositis.^[5]

A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.^[6]

• Tβ4 (thymosin beta-4) been found to play an important role in protection, regeneration and remodeling of injured or damaged tissues.

* This content is not intended to replace conventional medical treatment. Any suggestions made and all herbs listed are not intended to diagnose, treat, cure or prevent any disease, condition or symptom. Personal directions and use should be provided by a clinical herbalist or other qualified healthcare practitioner.

References

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Chan, J. (2011). Shinya Yamanaka, Induced Pluripotent Stem Cell (iPS) Pioneer. Asian Scientist. News and News and Information from the Asian Scientific community. http://www.asianscientist.com/features/shinya-yamanka-induced-pluripotent-stem-cell-ips/.

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Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent

Author(s): Mateus Machado Bergamaschi, Regina Helena Costa Queiroz, Antonio Waldo Zuardi and Jose Alexandre S. Crippa

Affiliation: Departamento de Neurociencias e Ciencias do Comportamento, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Hospital das Clinicas - Terceiro Andar, Av. Bandeirantes, 3900, Ribeirao Preto, ZIP Code: 14049-900, Sao Paulo, Brazil.